I’ve always been driven by a curiosity about how genetic variation leads to variation in phenotypes. Before switching to human research, my academic research focused on different fish study systems. My projects involved analyses of large –omics data sets which made me passionate about learning, developing, and applying new bioinformatics approaches.

The genetic basis of complex adaptive traits

pupfish

Evolutionary radiations showcase astounding examples of adaptation and are often characterized by transitions from generalist to specialist phenotypes. For my dissertation at UNC Chapel Hill, I studied a fascinating radiation of Cyprinodon pupfishes to understand how little genetic differentiation between three young species gave rise to drastic divergence in specialized traits. This radiation consists of a dietary generalist species and two derived trophic niche specialists that feed on novel resources. I discovered candidate alleles under selection that likely contribute to adaptive differences in adaptive craniofacial morphology. I also found evidence suggesting that some of these alleles negatively interact in hybrids to cause gene misregulation, which may act as an important barrier to gene flow during early stages of speciation in sympatry.

For more see my fishfASE repo


From oceans to rivers and lakes

fundulus

My postdoctoral research in Andrew Whitehead’s lab continued to explore questions related to adaptation and speciation. For one main project, I studied a radiation of Fundulus fishes that occupy diverse osmotic environments to understand adaptations that allowed freshwater specialists to evolve from marine-dwelling ancestors. Since this transition occurred several times independently across multiple clades, I searched for parallel and divergent gene regulatory mechanisms underlying freshwater adaptations by identifying cross-species differential gene expression in response to osmotic stress. This project is in collaboration with Lisa Johnson

For more see the RNAseq_17killifish_osmotic repo


The genomics of population collapse and recovery

herring

For another main project, I analyzed genomic samples from several populations of Pacific herring to understand the impacts of the Exxon Valdez oil spill on population collapse and lack of recovery in Prince William Sound, Alaska. The herring fishery in Prince William Sound declined by 75% from 1988 to 1993 and has yet to recover 27 years later. I used spatial and temporal genomic contrasts to discover changes in allele frequencies pre- and post-collapse that could help to explain the lack of population recovery. This project is in collaboration with Vince Buffalo

For more see my pac_herring repo


Talks

2021

Invited speaker. Center for Population Biology Graduate Group Seminar. University of California, Davis. Watch on YouTube

2020

Public Defense. University of North Carolina, Chapel Hill, NC. Watch on YouTube

2019

Contributed talk. Society for the Study of Evolution meeting. Providence, RI. Watch on YouTube

Invited speaker. Research in Progress Seminar Series. East Carolina University. Greensville, NC.

2018

Contributed talk. Society for Integrative and Comparative Biology meeting. San Francisco, CA.

Contributed talk. Society for the Study of Evolution meeting. Portland, OR. Watch on YouTube

Contributed talk. SouthEastern Population Ecology and Evolutionary Genetics Conference. Laurel Hill NC.


Data Links

Cyprinodon pupfish genomes and transcriptomes

drawing

Raw .fastq files related to pupfish publications are uploaded on the NCBI BioProject database. Accession PRJNA391309

Fundulus genome assemblies and transcriptomes

drawing

Genome assemblies for 4 killifish OSF DOI: 10.17605/osf.io/zjv86

Gene expression tables (Salmon read counts) OSF DOI: 10.17605/OSF.IO/M4XEG

Raw .fastq data NCBI BioProject Accession PRJNA473009

Pacific herring genomes

drawing

Raw .fastq data NCBI BioProject Accession PRJEB27171